3/3/2023 0 Comments Atresia Das Vias Biliares Pdf![]() For all association measures, we planned to use 95% confidence intervals (CIs) as well as Trial Sequential Analysis‐adjusted CIs. We planned to calculate risk ratios (RRs) for dichotomous outcomes, and the mean difference (MD) for continuous outcomes. We considered a P value of 0.025 or less, two‐tailed, as statistically significant. We performed the analyses using Review Manager 5.3 and Trial Sequental Analysis software. We analysed data using both random‐effects and fixed‐effect models. We assessed the risk of bias for each trial according to prespecified domains. We used standard methodological procedures expected by Cochrane. For harm, we also considered quasi‐randomised studies, observational studies, and case‐control studies that were identified amongst the search results. We included randomised clinical trials which assessed glucocorticosteroids for infants who have undergone Kasai portoenterostomy. We searched the Cochrane Hepato‐Biliary Group Controlled Trials Register, Cochrane Central Register of Controlled Trials (CENTRAL) in the Cochrane Library, MEDLINE Ovid, Embase Ovid, Science Citation Index Expanded (Web of Science), and online trial registries (last search: 20 December 2017) for randomised controlled trials. ![]() To assess the beneficial and harmful effects of glucocorticosteroid administration versus placebo or no intervention following Kasai portoenterostomy in infants with biliary atresia. Glucocorticosteroids are used to improve the postoperative outcomes in infants who have undergone Kasai portoenterostomy. ![]() Glucocorticosteroids are steroid hormones which act on the glucocorticoid receptor and have a range of metabolic and immunomodulatory effects. ![]() The mainstay of treatment is Kasai portoenterostomy, as soon as the disease has been confirmed. Biliary atresia is a life‐threatening disease characterised by progressive destruction of both intra‐ and extra‐hepatic biliary ducts. ![]()
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